Tubastatin_A_HCl, HDAC-6 inhibitor, 25mg, CAS# 1310693-92-5
$195.00
N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Purity: 99% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4530-25mg-EA
Tubastatin_A_HCl, HDAC-6 inhibitor, 25mg, CAS# 1310693-92-5 is available to buy in increments of 1
Product Details
Download Details and SpecificationsTubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and anti-rheumatic effects in Freund's competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5
CAS Number: 1310693-92-5
Manufacturer Part Number/SKU: 10-4530-25mg-EA
Tags: Focus Biomolecules