Trametiglue, MEK inhibitor / molecular glue, 5mg, CAS# 2666940-97-0
$100.00
N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H-yl)phenyl)methylaminosulfonamide Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3961-5mg-EA
Trametiglue, MEK inhibitor / molecular glue, 5mg, CAS# 2666940-97-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsTrametiglue is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50's/cell line - SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
CAS Number: 2666940-97-0
Manufacturer Part Number/SKU: 10-3961-5mg-EA
Tags: Focus Biomolecules