TH588, MTH1/NUDT1 inhibitor, 5mg, CAS# 1609960-31-7
$65.00
N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine hydrochloride Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4602-5mg-EA
TH588, MTH1/NUDT1 inhibitor, 5mg, CAS# 1609960-31-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsTH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that "sanitizes" oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3
CAS Number: 1609960-31-7
Manufacturer Part Number/SKU: 10-4602-5mg-EA
Tags: Focus Biomolecules