Tepotinib, c-Met inhibitor, 5mg, CAS# 1100598-32-0
$60.00
3-(1-(3-(5-((1-Methylpiperidin-4-yl)methoxy)pyrimidin-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)benzonitrile Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5322-5mg-EA
Tepotinib, c-Met inhibitor, 5mg, CAS# 1100598-32-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsTepotinib is a selective type 1b MET inhibitor. In biochemical assays using His6-tagged recombinant human MET kinase domain, tepotinib inhibited kinase activity in a concentration-dependent manner with IC50=1.8 nM.1 It displays marked antitumor activity in MET-dependent tumor models.2 It crosses the blood-brain barrier and displays intracranial antitumor activity.3 Tepotinib can overcome EGFR inhibitor resistance mediated by aberrant c-Met activation4 and is in clinical use for non-small cell lung cancer harboring MET exon 14 skipping alterations.
CAS Number: 1100598-32-0
Manufacturer Part Number/SKU: 10-5322-5mg-EA
Tags: Focus Biomolecules