SX-682, CXCR1/2 inhibitor, 5mg, CAS# 1648843-04-2
$90.00
[2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4925-5mg-EA
SX-682, CXCR1/2 inhibitor, 5mg, CAS# 1648843-04-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM)1. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.2 It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy.3 SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.4,5
CAS Number: 1648843-04-2
Manufacturer Part Number/SKU: 10-4925-5mg-EA
Tags: Focus Biomolecules