Streptonigrin, Induces heterochromatin formation, 1mg, CAS# 3930-19-6
$180.00
Fermentation product from Streptomyces flocculus Purity: >95% HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3484-1mg-EA
Streptonigrin, Induces heterochromatin formation, 1mg, CAS# 3930-19-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsStreptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
CAS Number: 3930-19-6
Manufacturer Part Number/SKU: 10-3484-1mg-EA
Tags: Focus Biomolecules