ß-Lapachone, Topoisomerase I inhibitor, 5mg, CAS# 4707-32-8
$52.00
3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2386-5mg-EA
ß-Lapachone, Topoisomerase I inhibitor, 5mg, CAS# 4707-32-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of b-lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFkB.5
CAS Number: 4707-32-8
Manufacturer Part Number/SKU: 10-2386-5mg-EA
Tags: Focus Biomolecules