SMED-1, Dexamethasone sensitizer, 25mg, CAS# N/A
$180.00
2-(4-Chlorophenoxy)-2-methyl-N-(2-(piperidin-1-yl)phenyl)propanamide Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1606-25mg-EA
SMED-1, Dexamethasone sensitizer, 25mg, CAS# N/A is available to buy in increments of 1
Product Details
Download Details and SpecificationsA dexamethasone (Dex) sensitizer. SMED-1 was discovered in a screen designed to identify compounds that sensitize Dex-resistant ALL xenografts to Dex.1 The assay employed Dex-resistant ALL-19 cells which are resistant at concentrations up to 850 μM. In contrast ALL-3 cells are sensitive to nanomolar concentrations of Dex (IC50=12 nM).2 SMED-1 displays strong synergism at 10 μM plus 1 μM Dex and exhibits little activity alone (IC50>20 μM). SMED-1 is Dex-synergistic in ALL-3, ALL-4 and ALL-16 xenografts but is antagonistic with ALL-31. Synergy is highest when drugs are given simultaneously.1
Manufacturer Part Number/SKU: 10-1606-25mg-EA
Tags: Focus Biomolecules