SJ6986, GSPT1 molecular glue, 5mg, CAS# 2765625-93-0
$55.00
N-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3933-5mg-EA
SJ6986, GSPT1 molecular glue, 5mg, CAS# 2765625-93-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
CAS Number: 2765625-93-0
Manufacturer Part Number/SKU: 10-3933-5mg-EA
Tags: Focus Biomolecules