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Adavosertib, Wee1 kinase inhibitor, 25mg, CAS# 955365-80-7

Adavosertib, Wee1 kinase inhibitor, 25mg, CAS# 955365-80-7

IPI-549, PI3Kγ inhibitor, 25mg, CAS# 1693758-51-8

IPI-549, PI3Kγ inhibitor, 25mg, CAS# 1693758-51-8

Sitravatinib, Multikinase inhibitor / Immuno-oncology agent, 25mg, CAS# 1123837-84-2

$200.00
1-N’-[3-Fluoro-4-[2-[5-[(2-methoxyethylamino)methyl]pyridin-2-yl]thieno[3,2-b]pyridin-7-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-4826-25mg-EA
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Sitravatinib, Multikinase inhibitor / Immuno-oncology agent, 25mg, CAS# 1123837-84-2 is available to buy in increments of 1

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Sitravatinib is a broad spectrum receptor tyrosine kinase inhibitor. Its targets include Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3 among others at nanomolar levels.1 Sitravatinib has been tested in mouse models of sarcoma and showed better efficacy than both imatinib and crizotinib. Because of its unique kinase inhibition profile (especially that of TAM receptors), it has been used to restore response to anti-PD-1 therapy (nivolumab) in NSCLC patients.2 Sitravatinib was able to significantly alter the immunosuppressive tumor microenvironment in three preclinical tumor models to enhance the effects of PD-1 blockade therapy.3

CAS Number: 1123837-84-2

Manufacturer Part Number/SKU: 10-4826-25mg-EA

Tags: Focus Biomolecules