SI-2, Potent inhibitor of steroid receptor coactivator-3 (SRC-3), 25mg, CAS# 380537-35-9
$230.00
1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3903-25mg-EA
SI-2, Potent inhibitor of steroid receptor coactivator-3 (SRC-3), 25mg, CAS# 380537-35-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSi-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3
CAS Number: 380537-35-9
Manufacturer Part Number/SKU: 10-3903-25mg-EA
Tags: Focus Biomolecules