SHP099, SHP2 inhibitor, 25mg, CAS# 1801747-42-1
$260.00
6-(4-Amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4604-25mg-EA
SHP099, SHP2 inhibitor, 25mg, CAS# 1801747-42-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSHP099 is a potent (IC50 = 71 nM) and selective allosteric inhibitor of SHP2. SHP2 is a non-receptor tyrosine phosphatase that regulates cell survival and proliferation through activating the RAS-ERK pathway. It also mediates programmed cell death 1 (PD-1) and T-lymphocyte attenuator (BTLA) immune checkpoint pathways. Treatment with SHP099, in combination with ceritinib, halts growth of ALK-inhibitor resistant non-small-cell lung cancer cells.3 Thus, reduction of SHP2 activity is a potential important cancer therapy target. It showed no activity against a panel of 21 other human phosphatases and 66 kinases.
CAS Number: 1801747-42-1
Manufacturer Part Number/SKU: 10-4604-25mg-EA
Tags: Focus Biomolecules