SC-560, Selective COX-1 inhibitor, 25mg, CAS# 188817-13-2
$195.00
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole Purity: >98% Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2531-25mg-EA
SC-560, Selective COX-1 inhibitor, 25mg, CAS# 188817-13-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50's = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells - it remained COX-1 specific in cell lysates.2
CAS Number: 188817-13-2
Manufacturer Part Number/SKU: 10-2531-25mg-EA
Tags: Focus Biomolecules