SBI-553, ß-Arrestin-biased NTSR1 modulator, 5mg, CAS# 1849603-72-0
$90.00
2-[[2-(1-Fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl]methylamino]ethanol Purity: >98% by HPLC NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4449-5mg-EA
SBI-553, ß-Arrestin-biased NTSR1 modulator, 5mg, CAS# 1849603-72-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSBI-553 is a potent, brain penetrant, and orally bioavailable allosteric modulator of neurotensin receptor 1 (NTSR1; EC50 = 340 nM)).1 It acts as a ß-Arrestin-biased agonist and selectively antagonizes G protein signaling conferring profound ß-Arrestin bias towards the endogenous ligand.2,3 SBI-553 displayed efficacy in mouse models of psychostimulant abuse without the characteristic undesirable side effects of unbiased NTSR1 agonism. This functionally selective modulation of NTSR1 may be a new therapeutic approach to treating psychostimulant abuse and other chemical and behavioral addictions.
CAS Number: 1849603-72-0
Manufacturer Part Number/SKU: 10-4449-5mg-EA
Tags: Focus Biomolecules