Salubrinal, eIF2α Phosphatase inhibitor, 5mg, CAS# 405060-95-9
$55.00
3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Purity: 98% by TLC [1% methanol in methylene chloride Rf = 0.35] Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4517-5mg-EA
Salubrinal, eIF2α Phosphatase inhibitor, 5mg, CAS# 405060-95-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsEndoplasmic reticulum (ER) stress inhibitor. Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3
CAS Number: 405060-95-9
Manufacturer Part Number/SKU: 10-4517-5mg-EA
Tags: Focus Biomolecules