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2E151, Vaccine co-adjuvant, 10mg, CAS# 2416963-37-4

2E151, Vaccine co-adjuvant, 10mg, CAS# 2416963-37-4

IDE1, Inducer of definitive endoderm, 5mg, CAS# 1160927-48-9

IDE1, Inducer of definitive endoderm, 5mg, CAS# 1160927-48-9

S07-2010, pan-AKR1C inhibitor, 5mg, CAS# 1223194-71-5

$80.00
7-(2-((6-Oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetyl)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-4148-5mg-EA
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S07-2010, pan-AKR1C inhibitor, 5mg, CAS# 1223194-71-5 is available to buy in increments of 1

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S07-2010 is a pan-aldo-keto reductase 1C (AKR1C) inhibitor (IC50's for AKR1C isoforms: 1C1 = 470 nM, 1C2 = 730 nM, 1C3 = 190 nM, 1C4 = 360 nM). Dysregulated AKR1C3 expression (and overexpression of all AKR1C isoforms in general) is related to resistance to radio- and chemotherapy in various tumor types and is associated with development of and poor prognosis in many cancers. S07-2010 displayed cytotoxicity to doxorubicin-resistant MCF-7 cells (IC50 = 127.5 µM) and cisplatin-resistant A549 cells (IC50 = 5.51 µM). Combination treatment of chemotherapeutic agents and S07-2010 showed synergistic effects in drug-resistant cell lines.

CAS Number: 1223194-71-5

Manufacturer Part Number/SKU: 10-4148-5mg-EA

Tags: Focus Biomolecules