RU.521, cGAS inhibitor, 25mg, CAS# 2262452-06-0
$325.00
3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4140-25mg-EA
RU.521, cGAS inhibitor, 25mg, CAS# 2262452-06-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
CAS Number: 2262452-06-0
Manufacturer Part Number/SKU: 10-4140-25mg-EA
Tags: Focus Biomolecules