RMC-7977, KRAS inhibitor, 5mg, CAS# 2765082-12-8
$295.00
Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3954-5mg-EA
RMC-7977, KRAS inhibitor, 5mg, CAS# 2765082-12-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsRMC-7977 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1
CAS Number: 2765082-12-8
Manufacturer Part Number/SKU: 10-3954-5mg-EA
Tags: Focus Biomolecules