Pyridone 6, pan-JAK inhibitor, 1mg, CAS# 457081-03-7
$60.00
2-(tert-Butyl)-9-fluoro-1Hbenzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5555-1mg-EA
Pyridone 6, pan-JAK inhibitor, 1mg, CAS# 457081-03-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent, ATP-competitive pan-JAK inhibitor. Inhibits 1, 2 and 3 (IC50=1, 5 and 15 nM respectively) as well as JAK family member Tyk2 (IC50=1 nM).1 Also tested against 21 other kinases with inhibition ranging from 130 nm to >10 mM. Inhibits IL2 and IL4-dependent proliferation of CTLL cells.1 Induces intermediate mesoderm differentiation from embryonic stem cells in a cocktail with LY-294002, CCG-1423 and retinoic acid.2 Potently inhibits STAT1, STAT5 and STAT6 phosphorylation and ameliorates allergic skin inflammation in a mouse model.3 Suppresses asthmatic responses in a mouse allergic asthma model.4
CAS Number: 457081-03-7
Manufacturer Part Number/SKU: 10-5555-1mg-EA
Tags: Focus Biomolecules