PTC-209, BMI-1 inhibitor, 25mg, CAS# 315704-66-6
$225.00
N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazol[1,2-a]pyrimidin-3-yl)-2-thiazolamine Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4022-25mg-EA
PTC-209, BMI-1 inhibitor, 25mg, CAS# 315704-66-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAn inhibitor of BMI-1 (IC50 = 500 nM), part of the polycomb repressive complex 1 (PCR1).1 It inhibited endogenous BMI-1 expression in human colorectal HCT116 and human fibrosarcoma HT1080 tumor cells resulting in reduced tumor volume as well as reduced cancer initiating cell (CIC) number. PTC-209 displayed potent in vivo antitumor effects in several cancer models including breast2, head and neck3, glioblastoma4, prostate5, colon5, and rhabdomyosarcoma6. It also promoted chemically-induced direct cardiac reprogramming of cardiac fibroblasts into cardiac myocytes.7,8
CAS Number: 315704-66-6
Manufacturer Part Number/SKU: 10-4022-25mg-EA
Tags: Focus Biomolecules