PRT4165, E3 ubiquitin ligase inhibitor, 10mg, CAS# 31083-55-3
$65.00
2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione Purity: 98% by TLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1478-10mg-EA
PRT4165, E3 ubiquitin ligase inhibitor, 10mg, CAS# 31083-55-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2
CAS Number: 31083-55-3
Manufacturer Part Number/SKU: 10-1478-10mg-EA
Tags: Focus Biomolecules