PRIMA-1MET, Reactivates mutant p53, 25mg, CAS# 5291-32-7
$165.00
2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Purity: 95% Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4175-25mg-EA
PRIMA-1MET, Reactivates mutant p53, 25mg, CAS# 5291-32-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPRIMA-1MET reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1 It induces p53-dependent mitochondrial apoptosis via activation of caspase-2.2 PRIMA-1MET showed significant antitumor activity in multiple myeloma via activation of p733 and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1MET has been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7 PRIMA-1MET probably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
CAS Number: 5291-32-7
Manufacturer Part Number/SKU: 10-4175-25mg-EA
Tags: Focus Biomolecules