Ponatinib, Bcr-Abl and multikinase inhibitor, 25mg, CAS# 943319-70-8
$170.00
3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5064-25mg-EA
Ponatinib, Bcr-Abl and multikinase inhibitor, 25mg, CAS# 943319-70-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsHighly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1 Also inhibits PDGFRa, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2 as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4
CAS Number: 943319-70-8
Manufacturer Part Number/SKU: 10-5064-25mg-EA
Tags: Focus Biomolecules