POB, Ornithine decarboxylase inhibitor, 50mg, CAS# 946135-39-3

Pyridoxal 5'-phosphate - dependent ornithine decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and a potential cancer drug target. POB is a transition state-based, cell permeable pro-drug inhibitor of ODC. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 µM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO.

CAS Number: 946135-39-3

Manufacturer Part Number/SKU: 10-4553-50mg-EA

Tags: Focus Biomolecules