PF-543_HCl, Sphingosine kinase-1 inhibitor, 25mg, CAS# 1706522-79-3
$270.00
[(2R)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol hydrochloride Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4998-25mg-EA
PF-543_HCl, Sphingosine kinase-1 inhibitor, 25mg, CAS# 1706522-79-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5
CAS Number: 1706522-79-3
Manufacturer Part Number/SKU: 10-4998-25mg-EA
Tags: Focus Biomolecules