PF-4136309, CCR2 antagonist, 5mg, CAS# 1341224-83-6
$75.00
N-[2-[(3S)-3-[[4-Hydroxy-4-(5-pyrimidin-2-ylpyridin-2-yl)cyclohexyl]amino]pyrrolidin-1-yl]-2-oxoethyl]-3-(trifluoromethyl)benzamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4261-5mg-EA
PF-4136309, CCR2 antagonist, 5mg, CAS# 1341224-83-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPF-4136309 (1341224-83-6) is a potent (hIC50 = 5.2 nM, mIC50 = 13 nM, rIC50 = 17 nM) and selective inhibitor of CCR2.1 PF-4136309 significantly decreased inflammatory monocytes in a mouse model of pancreatic cancer.2 In combination therapy with the FOLFIRINOX regimen, PF-4136309 reversed immune suppression in the tumor microenvironment causing an influx of tumor infiltrating lymphocytes leading to overall enhanced efficacy in a phase 1b study.3
CAS Number: 1341224-83-6
Manufacturer Part Number/SKU: 10-4261-5mg-EA
Tags: Focus Biomolecules