PF-06835919, Ketohexokinase inhibitor, 5mg, CAS# 2102501-84-6
$295.00
2-[(1R,5S)-3-[2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]acetic acid Purity: >98% by HPLC Purity: NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3958-5mg-EA
PF-06835919, Ketohexokinase inhibitor, 5mg, CAS# 2102501-84-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPF-06835919 is a potent (IC50 = 10 nM KHK-C; 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade.1 It displayed high selectivity against other sugar kinases. PF-06835919 prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats.2 The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919.3 An interesting new tool to study metabolic and fatty liver diseases.
CAS Number: 2102501-84-6
Manufacturer Part Number/SKU: 10-3958-5mg-EA
Tags: Focus Biomolecules