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PD_325901, MEK inhibitor, 25mg, CAS# 391210-10-9

PD_325901, MEK inhibitor, 25mg, CAS# 391210-10-9

Prostratin, Promotes neuro-regeneration, 5mg, CAS# 60857-08-1

Prostratin, Promotes neuro-regeneration, 5mg, CAS# 60857-08-1

Pemetrexed, Antifolate; antitumor agent, 50mg, CAS# 357166-29-1

$240.00
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid Purity: disodium salt Purity: 98% by TLC and HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-2162-50mg-EA
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Pemetrexed, Antifolate; antitumor agent, 50mg, CAS# 357166-29-1 is available to buy in increments of 1

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Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5

CAS Number: 357166-29-1

Manufacturer Part Number/SKU: 10-2162-50mg-EA

Tags: Focus Biomolecules