Pazopanib, Multi-receptor tyrosine kinase inhibitor, 10mg, CAS# 444731-52-6
$40.00
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2158-10mg-EA
Pazopanib, Multi-receptor tyrosine kinase inhibitor, 10mg, CAS# 444731-52-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibits multiple receptor tyrosine kinases including VEGFR1,2 and 3 (IC50s=10, 30, 47 nM respectively) and PDGFRα, β and c-Kit (IC50s=71, 84, 74 nM respectively) and others such as FGFR.1 The drug targets both the tumor and endothelial cells in a mouse xenograft model of human multiple myeloma.2 It reduces joint pain and inhibits cartilage degeneration in rodent osteoarthritis models.3 VEGF inhibitors such as pazopanib have potential for treatment of neovascular age-related macular degeneration.4 In clinical use for renal cell carcinoma.5
CAS Number: 444731-52-6
Manufacturer Part Number/SKU: 10-2158-10mg-EA
Tags: Focus Biomolecules