P505-15, Highly selective Syk inhibitor, 5mg, CAS# 1370261-97-4
$75.00
2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide hydrochloride Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4650-5mg-EA
P505-15, Highly selective Syk inhibitor, 5mg, CAS# 1370261-97-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsP505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk).1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5
CAS Number: 1370261-97-4
Manufacturer Part Number/SKU: 10-4650-5mg-EA
Tags: Focus Biomolecules