Osimertinib, Mutant EGFR kinase inhibitor, 50mg, CAS# 1421373-65-0
$150.00
N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5036-50mg-EA
Osimertinib, Mutant EGFR kinase inhibitor, 50mg, CAS# 1421373-65-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsOsimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4
CAS Number: 1421373-65-0
Manufacturer Part Number/SKU: 10-5036-50mg-EA
Tags: Focus Biomolecules