NSC23766, Rac1 GTPase inhibitor, 5mg, CAS# 733767-34-5
$67.00
N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrocholoride Purity: 98% by TLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2731-5mg-EA
NSC23766, Rac1 GTPase inhibitor, 5mg, CAS# 733767-34-5 is available to buy in increments of 1
Product Details
Download Details and SpecificationsNSC-23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 μM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.
CAS Number: 733767-34-5
Manufacturer Part Number/SKU: 10-2731-5mg-EA
Tags: Focus Biomolecules