NR2E3 agonist 11a, NR2E3 agonist, 5mg, CAS# 911211-69-3
$100.00
2-Chloro-N-[4-[6-(cyclopropanecarbonylamino)-1H-benzimidazol-2-yl]phenyl]benzamide Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4866-5mg-EA
NR2E3 agonist 11a, NR2E3 agonist, 5mg, CAS# 911211-69-3 is available to buy in increments of 1
Product Details
Download Details and Specifications11a is an agonist of the photoreceptor-specific nuclear receptor (NR2E3; PNR; RNR), found in rod photoreceptor cells (EC50 = 141 nM ß-lactamase assay; 35 nM NCOR assay).1 An interesting tool for targeting age-related macular degeneration. 11a was able to increase p53 activation in uterine cancer tumors suggesting NR2E3 agonism as a new anti-cancer strategy.2 A previous study found that cytotoxicity of 11a was due to G1/S phase cell cycle arrest rather than NR2E3 agonism.3
CAS Number: 911211-69-3
Manufacturer Part Number/SKU: 10-4866-5mg-EA
Tags: Focus Biomolecules