NHI-2, LDHA inhibitor, 50mg, CAS# 1269802-97-2
$395.00
Methyl 1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-carboxylate Purity: 98% by HPLC Purity: NMR (Confirms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4555-50mg-EA
NHI-2, LDHA inhibitor, 50mg, CAS# 1269802-97-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsNHI-2 is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC50 in vitro = 14.7 µM (NADH), 10.5 µM (Pyruvate).1 NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC50 = 22.2 µM normoxic and 4.0 µM hypoxic; LPC006 cells IC50 = 17.8 µM normoxic and 1.1 µM hypoxic) with increased efficacy in a cancer cells hypoxic environment.2 LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.
CAS Number: 1269802-97-2
Manufacturer Part Number/SKU: 10-4555-50mg-EA
Tags: Focus Biomolecules