Neratinib, Dual EGFR and HER2 inhibitor, 20mg, CAS# 698387-09-6
$50.00
(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3658-20mg-EA
Neratinib, Dual EGFR and HER2 inhibitor, 20mg, CAS# 698387-09-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsNeratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50's= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 It's been shown to also inhibit MST1 (IC50 = 37.7 nM).4
CAS Number: 698387-09-6
Manufacturer Part Number/SKU: 10-3658-20mg-EA
Tags: Focus Biomolecules