NAcM-OPT, NEDD8 ligation inhibitor, 5mg, CAS# 2089293-61-6
$55.00
1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea Purity: 98% by HPLC/TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1636-5mg-EA
NAcM-OPT, NEDD8 ligation inhibitor, 5mg, CAS# 2089293-61-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1 It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1
CAS Number: 2089293-61-6
Manufacturer Part Number/SKU: 10-1636-5mg-EA
Tags: Focus Biomolecules