MLN4924, Nedd8 activating enzyme inhibitor, 5mg, CAS# 905579-51-3
$100.00
((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate Purity: 98% by TLC Purity: NMR conforms Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1311-5mg-EA
MLN4924, Nedd8 activating enzyme inhibitor, 5mg, CAS# 905579-51-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsMLN4924 is a potent and selective NEDD8-activating enzyme (NAE) inhibitor.1 It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice.2 Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma.3 Modulates tumor microenvironment.4 Blocks the neddylation of the DNA endonuclease CtIP, which promotes HDR in Cas9- and Cpf1-mediated gene editing. Part of the CRISPY mix for increasing precise gene editing.5 Cell permeable.
CAS Number: 905579-51-3
Manufacturer Part Number/SKU: 10-1311-5mg-EA
Tags: Focus Biomolecules