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OTUDin3, OTUD3 inhibitor, 5mg, CAS# 441290-65-9

OTUDin3, OTUD3 inhibitor, 5mg, CAS# 441290-65-9

AOH1996, PCNA inhibitor, 5mg, CAS# 2089314-64-5

AOH1996, PCNA inhibitor, 5mg, CAS# 2089314-64-5

ML792, SUMO-activating enzyme (SAE) inhibitor, 5mg, CAS# 1644342-14-2

$95.00
[(1R,2S,4R)-4-[[5-[1-[(3-Bromophenyl)methyl]pyrazole-3-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-4985-5mg-EA
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ML792, SUMO-activating enzyme (SAE) inhibitor, 5mg, CAS# 1644342-14-2 is available to buy in increments of 1

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ML792 is a potent (IC50's = 3 nM SUMO1; 11 nM SUMO2) and selective( IC50 = 32 µM for NEDD8-activating enzyme (NAE)) mechanism-based inhibitor of SUMO-activating enzyme (SAE).1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV)-positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2

CAS Number: 1644342-14-2

Manufacturer Part Number/SKU: 10-4985-5mg-EA

Tags: Focus Biomolecules