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UNC-2170 HCl, Methyl-lysine binding protein inhibitor, 5mg, CAS# 1648707-58-7

UNC-2170 HCl, Methyl-lysine binding protein inhibitor, 5mg, CAS# 1648707-58-7

DY131, Estrogen-related receptor ERRβ and ERRγ agonist, 25mg, CAS# 95167-41-2

DY131, Estrogen-related receptor ERRβ and ERRγ agonist, 25mg, CAS# 95167-41-2

ML323, USP1 - UAF1 inhibitor, 5mg, CAS# 1572414-83-5

$80.00
N-(4-(1H-1,2,3-Triazol-1-yl(benzyl)-5-methyl-2-(2-isopropylphenyl)pyrimidin-4-amine Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-1560-5mg-EA
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ML323, USP1 - UAF1 inhibitor, 5mg, CAS# 1572414-83-5 is available to buy in increments of 1

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Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 mM.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3

CAS Number: 1572414-83-5

Manufacturer Part Number/SKU: 10-1560-5mg-EA

Tags: Focus Biomolecules