ML239, Selective cancer stem cell killer, 5mg, CAS# 1378872-36-6
$65.00
(2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Purity: 98% by TLC Purity: NMr (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1417-5mg-EA
ML239, Selective cancer stem cell killer, 5mg, CAS# 1378872-36-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3
CAS Number: 1378872-36-6
Manufacturer Part Number/SKU: 10-1417-5mg-EA
Tags: Focus Biomolecules