ML210, GPX4 inhibitor / Ferroptosis inducer, 50mg, CAS# 1360705-96-9
$290.00
(4-(Bis(4-chlorophenyl)methyl)piperazine-1-yl)(5-methyl-4-nitroisoxazol-3-yl)methanone Purity: 99% by HPLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4002-50mg-EA
ML210, GPX4 inhibitor / Ferroptosis inducer, 50mg, CAS# 1360705-96-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
CAS Number: 1360705-96-9
Manufacturer Part Number/SKU: 10-4002-50mg-EA
Tags: Focus Biomolecules