MCC-950, NLRP3 inflammasome inhibitor, 25mg, CAS# 210826-40-7
$218.00
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2990-25mg-EA
MCC-950, NLRP3 inflammasome inhibitor, 25mg, CAS# 210826-40-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsMCC-950 was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-11. Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes2. Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)3. Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome4. A valuable new tool for exploring the pathophysiology of NLRP3.
CAS Number: 210826-40-7
Manufacturer Part Number/SKU: 10-2990-25mg-EA
Tags: Focus Biomolecules