M22, NEDD8 activating enzyme inhibitor, 25mg, CAS# 864420-54-2

Protein neddylation is a post-translational modification which transfers the ubiquitin-like protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic cascade and has been considered as a viable target for the development of new therapeutics for cancer.1 M22 (CAS 864420-54-2) is an inhibitor of NEDD8 activating enzyme (NAE) which was discovered by virtual screening of a small molecule library (50,000 compounds) against the active site of NAE.2 M22 is selective and reversible and inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay employing recombinant human NAE. It selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells and inhibits their growth (GI50 = 5.5 µM). It has been shown to inhibit tumor growth in a mouse xenograft model (at 60 mg/kg).2

CAS Number: 864420-54-2

Manufacturer Part Number/SKU: 10-5733-25mg-EA

Tags: Focus Biomolecules