LY2603618, Chk1 inhibitor, 25mg, CAS# 911222-45-2
$195.00
N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)urea Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4123-25mg-EA
LY2603618, Chk1 inhibitor, 25mg, CAS# 911222-45-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsLY2603618 is a potent (IC50 = 7nM) and selective (>1000x over Chk2) Checkpoint kinase 1 (Chk1) inhibitor.1 Chk1 is an important regulator of the DNA damage response - combination treatment of LY2603618 with other chemotherapeutic agents significantly increased tumor growth inhibition when compared to chemotherapeutic alone.2,3,4 LY2603618 caused a dramatic suppression of cell growth in MCF-7 and MDA-MB-231 human breast cancer cells via Chk1 inhibition induced upregulation of replication stress caused by oncogenes.5
CAS Number: 911222-45-2
Manufacturer Part Number/SKU: 10-4123-25mg-EA
Tags: Focus Biomolecules