LD2, PRMT9 inhibitor, 25mg, CAS# 1134334-55-6
$225.00
4-Chloro-8-methoxy-5-methyl-5H-pyrimido[5,4-b]indole Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4872-25mg-EA
LD2, PRMT9 inhibitor, 25mg, CAS# 1134334-55-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsLD2 is a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. It inhibited the viability of leukemia cells (IC50 = 2-7 µM in various cell lines). LD2 promoted DNA damage leading to cyclic GMP-AMP synthase (cGAS) activation and a type I IFN response. LD2 acted synergistically with anti-PD-1 mAb in an A20 lymphoma syngeneic model, an MA9 AML transplant model as well as a humanized AML mouse model. LD2 treatment led to leukemia stem cell ablation as well as an anticancer immune response.
CAS Number: 1134334-55-6
Manufacturer Part Number/SKU: 10-4872-25mg-EA
Tags: Focus Biomolecules