Larotrectinib, panTRK inhibitor, 5mg, CAS# 1223403-58-4
$60.00
(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide Purity: 98% by HPLC NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4832-5mg-EA
Larotrectinib, panTRK inhibitor, 5mg, CAS# 1223403-58-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsLarotrectinib is a potent (IC50's < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C).1 It is >100 fold selective against a panel of 229 kinases. Larotrectinib markedly attenuated bone cancer pain and significantly blocked the formation of neuroma-like structures and the sprouting of sensory nerve fibers. Larotrectinib caused substantial tumor regression in various cancers displaying TRK gene fusions.2-4 Larotrectinib is the first tissue agnostic drug approved by the FDA.
CAS Number: 1223403-58-4
Manufacturer Part Number/SKU: 10-4832-5mg-EA
Tags: Focus Biomolecules