Koningic_acid, Glyceraldehyde-3-phosphate dehydrogenase inhibitor, 1mg, CAS# 74310-84-2
$260.00
(2’S,5aS,6R,9aS)-1,5a,6,7,8,9a-Hexahydro-6-(1-methylethyl)-1-oxo-spiro[2-benzoxepin-9(3H)2’-oxirane]-4-carboxylic acid Purity: 95% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3326-1mg-EA
Koningic_acid, Glyceraldehyde-3-phosphate dehydrogenase inhibitor, 1mg, CAS# 74310-84-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsKoningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 μM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5
CAS Number: 74310-84-2
Manufacturer Part Number/SKU: 10-3326-1mg-EA
Tags: Focus Biomolecules