K-858, Kinesin Eg5 inhibitor, 5mg, CAS# 72926-24-0
$60.00
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Purity: 98% by TLC Purity: NMR( conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1312-5mg-EA
K-858, Kinesin Eg5 inhibitor, 5mg, CAS# 72926-24-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSelective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells1.
CAS Number: 72926-24-0
Manufacturer Part Number/SKU: 10-1312-5mg-EA
Tags: Focus Biomolecules