JQ1, Bromodomain inhibitor, 25mg, CAS# 1268524-69-1
$260.00
(6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester Purity: 98% by TLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1361-25mg-EA
JQ1, Bromodomain inhibitor, 25mg, CAS# 1268524-69-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsJQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.
CAS Number: 1268524-69-1
Manufacturer Part Number/SKU: 10-1361-25mg-EA
Tags: Focus Biomolecules