Irinotecan_HCl, Topoisomerase I inhibitor, 250mg, CAS# 136572-09-3
$240.00
(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2146-250mg-EA
Irinotecan_HCl, Topoisomerase I inhibitor, 250mg, CAS# 136572-09-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsIrinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
CAS Number: 136572-09-3
Manufacturer Part Number/SKU: 10-2146-250mg-EA
Tags: Focus Biomolecules